Restore My Sight Research Reference Hub

Scientific Research on Vision Decline and Ocular Repair

This page is a research reference hub that supports the educational guide on progressive vision symptoms. It contains no advertisements and no product promotions.

Educational Only
Peer-Reviewed Sources
No Ads / No Promotions
Updated as Evidence Evolves

This research page supports the educational guide on progressive vision symptoms. Read the main guide here.

1) Ocular repair & regenerative signals

Research in retinal support cells explores why mammalian eyes regenerate poorly compared to other species, and which molecular signals can act as “brakes” on regeneration.

Prox1 as a barrier to retinal regeneration (Müller glia)
Nature Communications (2025) — mechanistic work on Prox1 and regenerative potential

2) Corneal surface repair (limbal stem cells)

The corneal surface stays transparent through constant renewal. Limbal stem cells play a central role in maintaining the corneal epithelium and overall surface integrity.

Limbal stem cells of the corneal epithelium (classic review)
British Journal of Ophthalmology / PubMed (2000)
Identifying limbal stem cells (review, open access)
PMC (2013) — summary of concepts and research challenges
Prox1 in corneal injury/repair contexts
PubMed (2025) + ARVO/IOVS publication page

3) Flashes/floaters & urgent evaluation

A sudden increase in floaters, new flashes of light, or a shadow/curtain over vision can indicate retinal tears or detachment. These symptoms should be evaluated urgently by an eye-care professional.

Acute-onset floaters and flashes & clinical considerations
JAMA (2010) — evidence-based perspective referenced in evaluation
Management of retinal detachment (clinical review PDF)
BMJ (Jan 2026) — clinical review document
If you experience sudden flashes/floaters, a curtain/shadow, or rapid vision loss, seek urgent evaluation.

4) Oxidative stress & AMD biology

Reviews discuss how oxidative stress contributes to AMD biology and why many strategies focus on supporting tissue resilience and protecting retinal structures.

Oxidative stress in age-related macular degeneration (review)
PubMed (2025) — mechanistic perspective and newer targets

5) Dry eye & “film-like blur”

Dry eye can contribute to fluctuating blur, discomfort, and visual fatigue. Reviews summarize mechanisms, common risk factors, and why symptoms are often underestimated.

Dry eye disease overview (open access)
PMC (2024) — risk factors and pathophysiology overview

6) Screens & digital eye strain

Reviews discuss how prolonged screen use can relate to dryness and strain, including reduced blinking and visual fatigue. Evidence is nuanced, so interpretation matters.

Digital eye strain (comprehensive review)
PMC (2022)
Blue light exposure: ocular hazards & prevention (review)
PMC (2023) — highlights that everyday exposure evidence can be mixed

Notes on interpretation

Individual symptoms can have multiple causes. A paper discussing a mechanism does not equal a diagnosis. This page summarizes peer-reviewed sources for education and context.

  • If symptoms are sudden (new flashes/floaters, curtain/shadow, rapid vision loss), seek urgent evaluation.
  • Research evolves; this page can be updated as stronger evidence becomes available.
  • Education is not a substitute for medical care or individualized diagnosis.